Edurardo Arellano is believed to be one of the most sophisticated brothers and had taken control of the cartel, called The Tijuana Cartel or "Arellano Félix Organization". He was wanted by Mexican and United States authorities in connection with the smuggling of several tons of marijuana and cocaine from Mexico into the U.S. each year. He and his sister Enedina Arellano Félix became the leaders of the drug cartel after their brother Francisco Javier Arellano Félix was arrested by U.S. authorities in Baja California on August 16, 2006. His brother Ramon Arellano Felix, believed to be the most ruthless member, was eventually killed in a Mazatlán shootout with the Federal Police in February 2002. His other brother Benjamín Arellano Félix, "The mastermind", was arrested in March 2002.
Arellano was captured by the Mexican Federal Police after a shootout in Tijuana, Baja California, on October 26, 2008. Eduardo was sought by Interpol in 180 countries, and the U.S. State Department had been offering USD $5,000,000 for information leading to his arrest. Eduardo Arellano Félix was charged in the U.S. Southern District of California with conspiracy to import cocaine and marijuana.
Authorities say Arellano didn't go down without a fight, despite having his 11-year-old daughter near him. On the same day, the Mexican military also arrested other alleged lieutenant of the Tijuana Cartel in a separate incident: Luis Ramirez Vázquez, known as El Güero Camarón, or The Blond Shrimp. Although the arrests were blows to the Arellano Félix cartel it did not dismantle the organization, which is now being led by Eduardo's nephew, Luis Fernando Sánchez Arellano.
On September 1, 2012, he was extradited to the U.S. to face charges of money laundering and drug trafficking among other crimes. He is the last Arellano Félix brother named in a 2003 indictment to be extradited.